Non-cell-autonomous cancer progression from chromosomal instability
Chromosomal instability (CIN) is a driver of cancer metastasis, yet the extent to which this effect depends on the immune system remains…
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Papers
Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression
Chromosomal instability (CIN) and epigenetic alterations have been implicated in tumor progression and metastasis; yet how these two hallmarks of…
The emerging role of cancer cell plasticity and cell-cycle quiescence in immune escape
Molecular programs that control the function and the phenotype of stem cells are also active in cancer and confer properties…
Immunoediting of cancer metastasis by NK cells
Natural killer (NK) cells serve a critical role in the control of metastasis. NK cells are now shown to preferentially…
Shape-Shifting Stem Cells Are Key to Cancer Metastasis and Immune Evasion
Just as people tend to become stuck in their ways as they grow older so too do cells. Neurons in…
What Does Cancer Metastasis Have to Do with Wound Healing? More than You Might Think
Metastasis — the spreading of cancer to other regions in the body — is responsible for 90% of cancer deaths.…
L1CAM links regeneration to metastasis
NATURE CANCER – Metastasis competence can be acquired early in tumorigenesis, although its underlying molecular intricacies remain unclear. A recent…
Chromosomal Instability Drives Cancer Metastasis
Aneuploidy—the presence of abnormal numbers of chromosomes in a cell—is associated with cancer metastasis, but scientists have struggled to connect…
Chromosomal Instability Drives Metastasis Independent of Aneuploidy
Chromosomal instability (CIN), which results from ongoing chromosome segregation errors in mitosis, is associated with metastasis. However, it is not…
Deadly role of chromosomal instability in metastasis
Chromosomal instability produces cytosolic micronuclei that rupture and activate a viral response pathway, driving metastasis. Read Article >