Transforming lung cancer types
Lung cancer cells can escape targeted therapy by switching oncogenic drivers and cell identity. …
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Featured Publications
Non-cell-autonomous cancer progression from chromosomal instability
Chromosomal instability (CIN) is a driver of cancer metastasis, yet the extent to which this effect depends on the immune system remains…
Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression
NATURE COMMUNICATIONS – Chromosomal instability (CIN) and epigenetic alterations have been implicated in tumor progression and metastasis; yet how these…
Regenerative lineages and immune-mediated pruning in lung cancer metastasis
NATURE MEDICINE – Developmental processes underlying normal tissue regeneration have been implicated in cancer, but the degree of their enactment…
Chromosomal instability drives metastasis through a cytosolic DNA response
NATURE – Chromosomal instability is a hallmark of cancer that results from ongoing errors in chromosome segregation during mitosis. Although…
L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer
NATURE CANCER – Metastasis-initiating cells with stem-like properties drive cancer lethality, yet their origins and relationship to primary-tumor-initiating stem cells…
Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution
CELL REPORTS – Numerical chromosomal instability is a ubiquitous feature of human neoplasms. Due to experimental limitations, fundamental characteristics of…
Adult Human Glioblastomas Harbor Radial Glia-like Cells
Radial glia (RG) cells are the first neural stem cells to appear during embryonic development. Adult human glioblastomas harbor a…
Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to eribulin
SCIENCE TRANSLATIONAL MEDICINE – Resistance to drugs is common in cancer and is often caused by the multidrug resistance protein…