Using an integrated systems biology approach, the Laughney Lab develops innovative tools that systematically map genome-encoded components to context-dependent cellular and in vivo functions at the protein, cell and multi-cellular level. We apply these emerging techniques to understand how highly pleiotropic regulators can adapt multiple functions (both tumor-suppressive and pro-tumoral) during the evolution of cancer metastasis. We are affiliated with the Institute for Computational Biomedicine, the Department of Physiology, Biophysics and Systems Biology, the Department of Cell and Developmental Biology in the BCMB Allied Program, the Tri-Institutional PhD Program in Computational Biology and Medicine, and the Meyer Cancer Center at Weill Cornell Medicine.