Using an integrated systems biology approach, the Laughney Lab develops innovative tools that systematically map genome-encoded components to context-dependent cellular and in vivo functions at the protein, cell and multi-cellular level. We apply these emerging techniques to understand how highly pleiotropic regulators can adapt multiple functions (both tumor-suppressive and pro-tumoral) during the evolution of cancer metastasis. We are affiliated with the Institute for Computational Biomedicine, the Department of Physiology, Biophysics and Systems Biology, the Tri-Institutional PhD Program in Computational Biology and Medicine, and the Meyer Cancer Center at Weill Cornell Medicine.